P-body mRNA Decay
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes DDX6 and LSM14A are canonical P-body (processing body) components involved in mRNA decay and translational repression. BAZ2A is a bromodomain chromatin regulator. PCM1 is a centriolar satellite scaffold. RING1 (PRC1), EP300 (HAT), GATAD2B (NuRD), and MAX (MYC network) are chromatin/transcriptional regulators. WASHC2A is part of the WASH endosomal recycling complex. NUP214 is a nuclear pore component. The module combines mRNA processing/P-body biology with chromatin regulation. DDX6 and LSM14A as strong hub genes anchor this in mRNA decay/P-body biology, making that the primary label.
Genes
Most correlated modules
- Ubiquitin-Chromatin Regulation · correlation 0.88
- NF-κB Stress Signaling · correlation 0.86
- Innate Immune Stress · correlation 0.85
- BRD4 Chromatin Regulation · correlation 0.84
- Splicing & Transcription · correlation 0.83
- Telomere Maintenance · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.