Ubiquitin-Chromatin Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
USP9X is a major deubiquitinase regulating diverse substrates; ITCH is an E3 ubiquitin ligase; CALCOCO2 (NDP52) is a selective autophagy receptor; TET2 is a DNA demethylase with broad epigenetic roles; RCOR1 is part of the CoREST chromatin-remodeling complex; SUPT5H is a transcription elongation factor; RAF1 is a MAPK kinase; UBXN7 is a ubiquitin regulatory protein; DYRK1B is a kinase. The module combines ubiquitin-proteasome regulation with chromatin/epigenetic control, suggesting a ubiquitin-mediated chromatin regulatory program. Moderate coherence with many weak/moderate members reflects mixed sub-programs.
Genes
Most correlated modules
- Mitochondrial Fusion Stress · correlation 0.93
- Circadian Clock Regulation · correlation 0.93
- Autophagy Lysosomal Program · correlation 0.92
- Circadian Transcription · correlation 0.92
- PD-L1 Checkpoint Program · correlation 0.92
- NF-κB Stress Signaling · correlation 0.91
- Housekeeping Signaling · correlation 0.90
- MARCH Ubiquitin Ligase · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.