Actin Cytoskeleton Organization
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
DST (dystonin) is a giant cytoskeletal linker protein connecting actin, microtubules, and intermediate filaments; UTRN (utrophin) is an actin-binding protein homologous to dystrophin; PALLD (palladin) organizes the actin cytoskeleton; WIPF1 (WASp-interacting protein family) promotes actin polymerization; CLTC (clathrin heavy chain) mediates endocytosis and membrane trafficking; CD2AP scaffolds actin at membrane contacts; BRWD3 is a chromatin reader. The module is enriched for cytoskeletal organization genes, consistent with mast cell shape maintenance and membrane dynamics.
Genes
Most correlated modules
- Chromatin Cell Cycle · correlation 0.88
- RNA Decay Processing · correlation 0.87
- STAT6 IL-4 Signaling · correlation 0.83
- BRD4 Chromatin Regulation · correlation 0.83
- Histone Methylation Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.