Housekeeping Signaling
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
CSDE1 is an RNA-binding protein regulating mRNA stability and translation; IFNGR1 is the IFN-gamma receptor; STK10 is a lymphocyte-oriented kinase; AHNAK is a large scaffold protein; OSBP mediates lipid transfer at ER-endosome contacts; RAB7A controls late endosomal trafficking; ERCC6 is involved in transcription-coupled DNA repair; PACSIN2 mediates endocytosis; ANTXR2 is a surface receptor. The module is broadly expressed (uniform) with moderate expression, suggesting a general cellular maintenance and receptor signaling housekeeping program.
Genes
Most correlated modules
- Circadian Clock Regulation · correlation 0.91
- Ubiquitin-Chromatin Regulation · correlation 0.90
- NF-κB Stress Signaling · correlation 0.89
- Ubiquitin-Lysosomal Maintenance · correlation 0.89
- Mast Cell Identity · correlation 0.88
- MARCH Ubiquitin Ligase · correlation 0.87
- BRD4 Chromatin Regulation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.