Aminoacyl-tRNA Synthetase
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes SKIC3 (RNA helicase of SKI complex, cytoplasmic RNA surveillance), ERCC5/XPG (nucleotide excision repair endonuclease), EPRS1 (bifunctional glutamyl-prolyl-tRNA synthetase), LARS1 (leucyl-tRNA synthetase), RAD50 (DNA double-strand break repair), SMARCE1 (SWI/SNF chromatin remodeling), HMGN4 (chromatin architectural protein), SARS1 (seryl-tRNA synthetase), MRPL38 (mitochondrial ribosomal large subunit). The module is dominated by aminoacyl-tRNA synthetases (EPRS1, LARS1, SARS1) alongside DNA repair (ERCC5, RAD50) and RNA surveillance (SKIC3). This reflects a general genome/proteome maintenance housekeeping program. SKIC3 connects to SKIC8 in neighbor M27, reinforcing shared RNA surveillance across the batch.
Genes
Most correlated modules
- Protein Homeostasis · correlation 0.96
- Lysosomal Autophagy · correlation 0.92
- Histone Variant Chromatin · correlation 0.90
- MARCH Ubiquitin Ligase · correlation 0.90
- RNA Processing & Mitochondrial · correlation 0.90
- General Housekeeping · correlation 0.90
- tRNA Aminoacylation · correlation 0.89
- Mitochondrial Organization · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.