STAT6 IL-4 Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
STAT6 is the canonical transcription factor downstream of IL-4 and IL-13 signaling, central to mast cell activation, IgE-mediated responses, and type 2 immunity. GSK3B (glycogen synthase kinase 3β) phosphorylates and regulates multiple transcription factors including STAT6 pathway components. MTA2 is a core subunit of the NuRD chromatin remodeling complex that represses STAT6 target genes. PHF21A (PHD finger protein) is a chromatin reader involved in transcriptional repression. PPP3R1 (calcineurin B regulatory subunit) links calcium signaling to NFAT activation in mast cells. GRK3 desensitizes G protein-coupled receptors relevant to mast cell chemotaxis. PDCD6IP (ALIX) participates in ESCRT/exosome biogenesis. APLF is a DNA repair scaffold. The module reflects a STAT6-centered regulatory program with chromatin and signaling co-regulators, consistent with mast cell IL-4/IL-13 responsiveness.
Genes
Most correlated modules
- PI3K Inflammatory Signaling · correlation 0.91
- Vesicle ER Trafficking · correlation 0.87
- RNA & Membrane Housekeeping · correlation 0.86
- Actin Cytoskeleton Organization · correlation 0.83
- Cytoskeletal Organization · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.