DNA Damage Repair
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
Very low expression (0.025) and detection rate (2.1%) indicate a rare or lowly expressed program. Hub genes include NTHL1 (DNA glycosylase, base excision repair), FIGNL1 (fidgetin-like, DNA replication/repair), DCLRE1B (DNA cross-link repair/telomere maintenance), TP53 (DNA damage checkpoint), PSMC3IP (meiotic recombination/DNA repair), CEP290/CEP97 (centriole biogenesis), PASK (PAS kinase, metabolic/cell cycle). The module is enriched for DNA repair and genome integrity genes. The positive delta_remission_UC (0.258) may reflect recovery-associated DNA repair activity.
Genes
Most correlated modules
- DNA Replication Repair · correlation 0.79
- S-phase DNA Replication · correlation 0.77
- S-phase Replication · correlation 0.76
- Centrosome Biogenesis · correlation 0.73
- Proliferation RNA Processing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.