S-phase Replication
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes ORC6, CDT1, PCLAF, ASF1B, FEN1, CLSPN, TYMS, DHFR, HELLS are canonical S-phase DNA replication genes involved in origin licensing, Okazaki fragment processing, dNTP synthesis, and replication checkpoint. All genes are core members with uniform expression, consistent with a proliferating mast cell subpopulation. Tight coherence and neighbor modules M194 and M35 confirm a cell cycle neighborhood.
Genes
Most correlated modules
- FA DNA Repair · correlation 0.97
- S-phase DNA Replication · correlation 0.95
- DNA Replication · correlation 0.90
- Proliferation RNA Processing · correlation 0.90
- Mitotic Spindle · correlation 0.86
- Chromatin Remodeling · correlation 0.86
- G2/M Checkpoint · correlation 0.84
- OxPhos & RNA Processing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.