S-phase DNA Replication
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include NCAPG2 (condensin II, chromosome condensation), RANBP1 (RanGTPase, mitosis/nuclear transport), GMNN (geminin, replication licensing inhibitor, S/G2), EZH2 (PRC2 histone methyltransferase, active in proliferating cells), CDK2 (S-phase kinase), CDKN2D (p19, CDK inhibitor), BARD1 (BRCA1 partner, DNA repair), PAFAH1B3 (cell division), PPP1R7 (mitosis phosphatase regulator), LSM3 (RNA splicing, replication-coupled). CBR3, PMVK, SUCLG1, APOLD1, ECM1, C9orf40, CCDC167, POLR3K are less clearly cell-cycle but some (PMVK in mevalonate pathway supporting proliferation, POLR3K in RNA Pol III for growth). This module represents S-phase/DNA replication and chromatin regulation in proliferating cells, complementary to the M171 mitotic spindle module. Together they define a proliferating mast cell state.
Genes
Most correlated modules
- Proliferation RNA Processing · correlation 0.95
- S-phase Replication · correlation 0.95
- FA DNA Repair · correlation 0.93
- OxPhos & RNA Processing · correlation 0.92
- Mitotic Spindle · correlation 0.92
- Mitotic Spindle · correlation 0.90
- MHC-II Antigen Presentation · correlation 0.87
- Chromatin Remodeling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.