Centrosome Biogenesis
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include CARM1 (coactivator-associated arginine methyltransferase, chromatin/transcription regulation), CCDC18 (centrosome/cilia, cell cycle), ZGRF1 (DNA repair helicase), ARPC1A (Arp2/3 complex, actin branching), CDKN2A (p16/p14ARF, cell cycle inhibitor/senescence), CEP135 (centriole biogenesis), SLBP (histone mRNA processing, S-phase), MMS22L (DNA replication stress repair), TCHP (centriole), KIAA0753 (centriole/centrosome), CYFIP1 (WAVE complex, actin), ARHGAP11B (RhoGAP, cell division). CLDN4 (claudin-4, tight junction) and PCK2 (gluconeogenesis) are outliers. The module combines centrosome/centriole biogenesis with DNA repair and chromatin regulation, consistent with S/G2 phase preparation. Neighbor context (M171, M146 are cell cycle) supports this as another cell cycle sub-program focused on centrosome duplication and DNA repair.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.81
- DNA Damage Repair · correlation 0.73
- Chromatin Remodeling · correlation 0.73
- Mitotic Spindle · correlation 0.72
- S-phase DNA Replication · correlation 0.71
- Type I Interferon Response · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.