Proliferation RNA Processing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 28 genes have a known function matching the annotation |
Why this annotation
This module combines spliceosomal RNA processing genes (SNRPB, SNRPD1, SRSF9, SF3B6), cytoskeletal/tubulin genes (TUBB4B, TUBA1C), nuclear transport (RAN, KPNA2), cell cycle regulators (CKS2, UBE2S, NASP), and clathrin (CLTA). The higher expression (28% positive) and mixed membership suggest a general proliferation-associated housekeeping program coupling RNA processing with cytoskeletal dynamics. RAN is a shared hub with M133, linking nuclear transport across modules. The dominant RNA processing component justifies classification under RNA processing.
Genes
Most correlated modules
- S-phase DNA Replication · correlation 0.95
- OxPhos & RNA Processing · correlation 0.95
- S-phase Replication · correlation 0.90
- MHC-II Antigen Presentation · correlation 0.89
- FA DNA Repair · correlation 0.88
- Mitotic Spindle · correlation 0.85
- DNA Replication · correlation 0.84
- Mitotic Spindle · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.