DNA Replication Repair
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 36 genes have a known function matching the annotation |
Why this annotation
Hub genes MCM2, MCM8 (replicative helicase complex), SMC3 (cohesin, sister chromatid cohesion), CENPH (kinetochore), GINS2 (CMG replication fork helicase), RFC3 (replication factor C clamp loader), LIG1 (DNA ligase I, replication/repair), FANCA (Fanconi anemia DNA repair), MSH2 (mismatch repair) define a DNA replication and repair program. Distinct from M168 (pure S-phase initiation) by emphasis on repair pathways (Fanconi, MMR). TCF3 may reflect transcriptional regulation of the proliferative state.
Genes
Most correlated modules
- S-phase Replication · correlation 0.83
- DNA Damage Repair · correlation 0.79
- DNA Replication · correlation 0.75
- FA DNA Repair · correlation 0.74
- G2/M Checkpoint · correlation 0.69
- SWI/SNF Remodeling · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.