DNA Damage Response
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes include PARP1, RNF168, PPM1D, ING1, and KAT6A — all well-established DNA damage response and repair factors. RNF168 is a key E3 ubiquitin ligase in the DSB response (H2A ubiquitination), PPM1D/WIP1 is a DNA damage checkpoint phosphatase, PARP1 is central to base excision repair, ING1 is a p53-associated tumor suppressor involved in DNA damage sensing, and KAT6A is a histone acetyltransferase linked to chromatin remodeling at damage sites. CNOT10 (CCR4-NOT), SYMPK, and ZC3HAV1 add RNA surveillance/processing components. HEATR6 and NCOA7 contribute chromatin/transcriptional regulation. The module is uniformly expressed with low pct positive, consistent with a stress-response program active in a subset of mast cells. Negative delta_remission_UC suggests this program is suppressed during remission.
Genes
Most correlated modules
- SWI/SNF Remodeling · correlation 0.75
- Centrosome Biogenesis · correlation 0.73
- Intracellular Trafficking · correlation 0.69
- S-phase Histones · correlation 0.69
- Chromatin Epigenetic Regulation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.