SWI/SNF Remodeling
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
PBRM1 (BAF180) is the defining subunit of the PBAF SWI/SNF chromatin remodeling complex. BAZ1B is part of the WICH/WINAC chromatin remodeling complex. CDK19 is the kinase subunit of the Mediator-associated CDK8 module regulating transcription. RIF1 controls replication timing and DNA repair. MIS18BP1 is required for CENP-A deposition at centromeres. TUBGCP3 is a gamma-tubulin ring complex component for centrosome nucleation. NUP210 and NUP50 are nuclear pore components. DIAPH1 (mDia1) regulates actin polymerization and cytokinesis. The module centers on chromatin remodeling complexes with centromere/nuclear organization co-regulation.
Genes
Most correlated modules
- DNA Replication · correlation 0.88
- Mitotic Spindle · correlation 0.88
- Chromatin Remodeling · correlation 0.85
- FA DNA Repair · correlation 0.78
- S-phase Replication · correlation 0.76
- Centrosome Biogenesis · correlation 0.76
- S-phase Histones · correlation 0.75
- DNA Damage Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.