Chromatin Epigenetic Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub genes DDX17 (RNA helicase/splicing regulator), ATRX (chromatin remodeler/SWI/SNF-like), SENP7 (SUMO-specific protease acting on chromatin), KDM5A (H3K4 demethylase), ASH1L (H3K36 methyltransferase), BAZ2B (bromodomain/chromatin), GON4L (transcriptional regulator) form a coherent chromatin remodeling and epigenetic regulation program. LUC7L3, RBM26, TNRC6B add RNA processing/miRNA pathway components. TFDP2 (E2F dimerization partner) links to transcriptional control. CFLAR (cFLIP) is an apoptosis regulator. The module represents chromatin/epigenetic regulation co-expressed with RNA processing in mast cells.
Genes
Most correlated modules
- Immune Activation Signaling · correlation 0.85
- Histone Methylation Regulation · correlation 0.82
- Chromatin & Ubiquitin Regulation · correlation 0.81
- Integrin-Calcium Signaling · correlation 0.78
- SWI/SNF Remodeling · correlation 0.70
- Intracellular Trafficking · correlation 0.69
- DNA Damage Response · correlation 0.69
- Histone Ubiquitination · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.