Centrosome Biogenesis
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
CEP152 and CEP192 are master regulators of centriole biogenesis and PCM organization, essential for centrosome duplication. KIF18A is a kinesin that controls chromosome alignment on the mitotic spindle. NCAPD3 is a condensin II subunit required for chromosome condensation in mitosis. MCM6 marks DNA replication. NSMCE2 (MMS21) is the SUMO E3 ligase of the SMC5/6 complex involved in DNA repair. PARPBP (PARI) inhibits PARP1 at replication forks. NUP205 and NUP85 are nuclear pore scaffold components. PIDD1 activates p53 in response to centrosome amplification. The module centers on centrosome biogenesis and mitotic chromosome organization.
Genes
Most correlated modules
- S-phase Histones · correlation 0.81
- DNA Replication · correlation 0.77
- SWI/SNF Remodeling · correlation 0.76
- STAT5 Cytokine Signaling · correlation 0.74
- Pyroptosis Apoptosis Program · correlation 0.74
- Mitotic Spindle · correlation 0.73
- DNA Damage Response · correlation 0.73
- FA DNA Repair · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.