PI3K Inflammatory Signaling
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include PIK3CG (PI3K gamma, essential for mast cell and immune cell activation downstream of GPCRs and immune receptors), PDE3A (cAMP phosphodiesterase, regulates cAMP levels in immune cells), AKAP11 (A-kinase anchoring protein, scaffolds PKA signaling), IL1RAP (IL-1 receptor accessory protein, inflammatory cytokine signaling), NCOR2 (nuclear corepressor, transcriptional repression), and LRPPRC (mitochondrial RNA processing). The module is significantly elevated in UC inflammation and strongly reduced in remission, pointing to an inflammatory signaling program. PIK3CG, PDE3A, AKAP11, and IL1RAP collectively define a PI3K/cAMP/IL-1 inflammatory signaling axis relevant to mast cell activation in colitis.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.94
- Mast Cell Specification · correlation 0.93
- Mast Cell Identity · correlation 0.92
- Chromatin Remodeling · correlation 0.92
- Rho GTPase Signaling · correlation 0.91
- STAT6 IL-4 Signaling · correlation 0.91
- Mast Cell Homeostasis · correlation 0.91
- JAK-TEC Signaling · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.