Basal Mast Signaling
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include PLCG2 (phospholipase C gamma 2, central to FcεRI/BCR signaling in mast cells), SOS1 (RAS GEF, RTK signaling), ATP2A3 (SERCA3 calcium pump, calcium homeostasis), GAPVD1 (endosomal trafficking), and SLFN5 (immune cell growth regulator). Additional genes include UPF2/DIS3L (RNA surveillance), ABCD4 (peroxisomal transport), CEPT1 (phospholipid synthesis), and MTMR4 (phosphoinositide phosphatase). The module is a mixed housekeeping/basal signaling program with mast cell-relevant calcium and phospholipid signaling components. Low expression (23.3% positive), uniform across subsets, no significant disease association. PLCG2 and SOS1 are the most biologically specific genes but the overall module is heterogeneous.
Genes
Most correlated modules
- Mast Cell Signaling · correlation 0.83
- Mast Cell Degranulation · correlation 0.81
- Type I Interferon Response · correlation 0.65
- Leukotriene Biosynthesis · correlation 0.62
- Metabolic Redox Stress · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.