Metabolic Redox Stress
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include AKR1A1 (aldo-keto reductase, redox), PYCARD (ASC adaptor protein, inflammasome), SRM (spermidine synthase, polyamine metabolism), ATP5MC1 (ATP synthase), LDHA (lactate dehydrogenase, glycolysis), PRDX4 and PRDX6 (peroxiredoxins, ROS defense), FKBP1A (FK506-binding protein, immunophilin), NDUFC2 (Complex I), NEDD8 (neddylation), TALDO1 (transaldolase, pentose phosphate pathway), LAMTOR2 (Ragulator/mTORC1 lysosomal signaling), ATP5PF (ATP synthase), MRPL17/MRPS34/MRPS23 (mitochondrial ribosomes). The module combines metabolic (glycolysis, pentose phosphate, OxPhos), redox defense, and inflammasome (PYCARD) components. PYCARD/ASC is a key inflammasome scaffold relevant to mast cell inflammatory activation. The module is upregulated in UC inflammation and downregulated with CD treatment.
Genes
Most correlated modules
- Actin Cytoskeletal Dynamics · correlation 0.88
- Mast Cell Identity · correlation 0.84
- Mixed Housekeeping · correlation 0.84
- OxPhos & RNA Processing · correlation 0.79
- Mitochondrial OxPhos · correlation 0.78
- Mitochondrial OxPhos · correlation 0.77
- MHC-II Antigen Presentation · correlation 0.74
- Mast Cell Identity · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.