Mast Cell Signaling
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include BTK (mast cell/B cell kinase essential for mast cell activation), ORAI1 (store-operated calcium channel critical for mast cell degranulation and activation), FERMT3 (kindlin-3, integrin activation in hematopoietic cells), CAMK1 (calcium/calmodulin kinase), SOCS2 (cytokine signaling suppressor), FLCN (mTOR regulator), NDUFB3 (mitochondrial complex I), and ATP5F1D (ATP synthase). The module combines calcium signaling, kinase activity, and metabolic support genes relevant to mast cell activation and homeostasis. Uniform expression across subsets and moderate mean expression suggest a basal mast cell signaling state. Negative delta_remission_UC is consistent with activity in active disease.
Genes
Most correlated modules
- Mast Cell Degranulation · correlation 0.85
- Basal Mast Signaling · correlation 0.83
- MHC-II Antigen Presentation · correlation 0.79
- Mixed Housekeeping · correlation 0.77
- Actin Cytoskeletal Dynamics · correlation 0.75
- Leukotriene Biosynthesis · correlation 0.75
- Mast Cell Identity · correlation 0.73
- Metabolic Redox Stress · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.