Mast Cell Degranulation
Gene co-expression module in Mast cells
| Category | Degranulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub genes are canonical degranulation machinery: CD63 (lysosomal membrane protein released during degranulation), VAMP8 (v-SNARE mediating granule-plasma membrane fusion), STXBP5 (Munc18 family, SNARE complex regulator for exocytosis). MS4A2 encodes FcεRIβ, the high-affinity IgE receptor beta chain defining mast cell identity. CYBA encodes p22phox of NADPH oxidase (reactive oxygen species during activation). CASP4 links to inflammasome activation. DYNLL1 (dynein light chain) supports vesicle transport. TMSB4X sequesters actin during cytoskeletal remodeling. SLC5A3 (myo-inositol transporter) supports phosphoinositide signaling. Negative delta_remission_UC indicates activity in active disease. This module represents the mast cell degranulation program.
Genes
Most correlated modules
- Mast Cell Signaling · correlation 0.85
- Basal Mast Signaling · correlation 0.81
- Leukotriene Biosynthesis · correlation 0.78
- Mixed Housekeeping · correlation 0.78
- Co-transcriptional RNA Processing · correlation 0.74
- Inflammatory Mast Activation · correlation 0.72
- Mast Cell Identity · correlation 0.70
- Proteostasis & Translation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.