Pyroptosis Apoptosis Program
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes RBBP4 (chromatin assembly factor, NuRD/CAF-1 component), TRIM27 (RBCC E3 ubiquitin ligase, immune signaling), DDHD2 (phospholipase A1, lipid metabolism), ERLIN2 (ER lipid raft-associated), APAF1 (apoptosome scaffold, intrinsic apoptosis), GSDMD (gasdermin D, pyroptosis effector, inflammasome output), TYK2 (JAK family kinase, IFN/cytokine signaling), CDC25B (cell cycle phosphatase), RAD21 (cohesin, DNA repair/cell cycle), SUN2 (LINC complex, nuclear envelope). GSDMD and APAF1 together strongly implicate programmed cell death — pyroptosis and apoptosis respectively. TYK2 links to IFN signaling which can trigger both. RBBP4 and RAD21 add chromatin/cell cycle context. The module likely reflects an inflammasome/cell death regulatory program in mast cells, consistent with the strong negative delta_remission_UC (reduced in remission).
Genes
Most correlated modules
- STAT5 Cytokine Signaling · correlation 0.87
- Post-transcriptional Regulation · correlation 0.82
- Chromatin Remodeling · correlation 0.76
- Centrosome Biogenesis · correlation 0.74
- Mitotic Spindle · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.