STAT5 Cytokine Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
STAT5A is the top hub gene and a critical transcription factor downstream of SCF/KIT, IL-4, and IL-2 signaling in mast cells — central to mast cell survival and proliferation. VPS26B (retromer), EXOC6 (exocyst secretion complex), LRBA (vesicle trafficking, immune regulation), ATP8A1 (phospholipid flippase) suggest vesicle/membrane trafficking. KIF2A (microtubule depolymerizing kinesin), ERC1, MAPK9 (JNK2, stress/cytokine MAPK), TRIM28 (chromatin/transcriptional corepressor), TM7SF3 (ER stress/UPR), NNT (mitochondrial NADPH), PRDX3 (mitochondrial peroxiredoxin) add metabolic and regulatory components. The module is anchored by STAT5A-driven cytokine signaling with supporting trafficking and metabolic genes.
Genes
Most correlated modules
- Post-transcriptional Regulation · correlation 0.87
- Pyroptosis Apoptosis Program · correlation 0.87
- Histone Methylation Regulation · correlation 0.82
- Chromatin Remodeling · correlation 0.78
- Mitotic Spindle · correlation 0.77
- SWI/SNF Remodeling · correlation 0.74
- Centrosome Biogenesis · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.