Chromatin Remodeling
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub CXXC1 binds unmethylated CpG islands and regulates H3K4 methylation. SUZ12 is a PRC2 core subunit (H3K27me3). SSRP1 is part of the FACT histone chaperone complex. ATAD2 is a chromatin reader upregulated in proliferating cells. MCM3 marks DNA replication. FAM111A associates with replication forks. MAZ is a transcription factor. P4HB and RPN2 are ER-resident but peripheral. The dominant program is epigenetic/chromatin remodeling in proliferating cells, consistent with the neighboring cell cycle modules.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.88
- S-phase Replication · correlation 0.86
- FA DNA Repair · correlation 0.85
- SWI/SNF Remodeling · correlation 0.85
- S-phase DNA Replication · correlation 0.85
- DNA Replication · correlation 0.84
- Mitotic Spindle · correlation 0.83
- Mitotic Spindle · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.