Post-transcriptional Regulation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF4EBP2 (translation regulation), MAP2K5 (MAPK signaling), CXCR4 (chemokine receptor), NONO and TAF15 (RNA-binding/transcription), CPSF1 (mRNA 3' processing), MEX3C (RNA binding), UNK (RNA binding), MTA1 (chromatin remodeling), CIZ1 (DNA replication licensing). The module combines RNA processing, transcriptional regulation, and signaling components with uniform low expression across subsets. No single dominant biological program emerges; the mixture of RNA-binding proteins (NONO, TAF15, UNK, MEX3C, CPSF1) with signaling kinases and chromatin regulators suggests a broadly expressed post-transcriptional regulatory module. The strongest coherent sub-theme is RNA processing and gene regulation.
Genes
Most correlated modules
- STAT5 Cytokine Signaling · correlation 0.87
- Pyroptosis Apoptosis Program · correlation 0.82
- Histone Methylation Regulation · correlation 0.82
- Integrin-Calcium Signaling · correlation 0.78
- Mast Cell Transcription · correlation 0.76
- UPR Secretory Stress · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.