Chromatin Transcriptional Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly enriched for chromatin remodeling and transcriptional regulation: RYBP (PRC1 Polycomb repressive complex), CHD4 (NuRD chromatin remodeling complex ATPase), NCOA1 (nuclear receptor coactivator), MED13 (Mediator transcription complex subunit), IRF2BP2 (transcriptional repressor), SNAPC1 (snRNA-activating protein complex), ZRANB1 (deubiquitinase with chromatin roles), PURB (purine-rich element binding transcription factor), CREB3L2 (bZIP transcription factor), MDM4 (p53 regulator). HNRNPH1 and SRSF6 add RNA splicing. The dominant program is chromatin-level transcriptional regulation, consistent with neighbor M86 which also features histone-modifying enzymes.
Genes
Most correlated modules
- Mast Cell Activation · correlation 0.81
- Protein Biogenesis Housekeeping · correlation 0.74
- Proteostasis & Translation · correlation 0.71
- Co-transcriptional RNA Processing · correlation 0.71
- RNA Splicing · correlation 0.70
- Pre-mRNA Splicing · correlation 0.70
- Mixed Splicing Stress · correlation 0.69
- Housekeeping Maintenance · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.