Immune Checkpoint State
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
Top hub gene HAVCR2 (TIM-3) is an immune checkpoint receptor expressed on mast cells and other immune cells, associated with immune regulation and exhaustion. LYN is a Src-family kinase essential for mast cell FcεRI signaling and negative regulation. CD276 (B7-H3) is an immune checkpoint ligand. EPAS1 (HIF-2α) drives hypoxia response. STAB1 is a scavenger receptor on immunosuppressive cells. SPRY2 is a negative regulator of RTK/MAPK signaling. Together these suggest an immune-regulatory/checkpoint state in mast cells, potentially hypoxia-associated. Strong negative delta_remission_UC (-0.666) suggests this state is lost in remission.
Genes
Most correlated modules
- Actin Cytoskeleton Remodeling · correlation 0.74
- Mast Cell Signaling · correlation 0.71
- Cytoskeletal Signaling · correlation 0.65
- Mast Cell Signaling · correlation 0.65
- Mitochondrial Maintenance · correlation 0.63
- Actin Cytoskeletal Dynamics · correlation 0.62
- Leukotriene Biosynthesis · correlation 0.57
- Mitochondrial OxPhos · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.