IFN-gamma immunoproteasome
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 31 genes have a known function matching the annotation |
Why this annotation
This is a classic interferon-gamma-induced antigen-processing program. It contains the immunoproteasome subunits PSMB8 and PSMB9, the proteasome activators PSME1 and PSME2, other proteasome components (PSMA4, PSMA5, PSMB2, POMP), and the ubiquitin-like modifier binder NUB1. It also includes MHC class I genes (B2M, HLA-C, HLA-F) and IFN-gamma targets (WARS1, VAMP5, PLAAT4, SECTM1, TRIM69, CALHM6). Together these indicate MHC-I presentation in an inflamed colon.
Genes
Most correlated modules
- Classical monocyte identity · correlation 0.87
- Cytokine-responsive monocyte · correlation 0.84
- ER Membrane Homeostasis · correlation 0.79
- Type I Interferon · correlation 0.79
- BTN3A immunoregulatory · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.