Classical monocyte identity
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
This is a classical monocyte identity and innate-sensing module. MAFB is the monocyte/macrophage lineage transcription factor. MYD88 drives TLR signaling. IFITM2 and IFITM3 are typical of circulating classical monocytes, and APOBEC3G is a restriction factor. SERPINA1 and SAT1 are canonical classical-monocyte transcripts. HLA-E, LILRB1, CD47 and CD48 are inhibitory/self-recognition receptors. It neighbors the M11 monocyte (PLAC8/LILRB4) and M114 interferon-gamma/antigen-presentation modules. Together these indicate a newly recruited, blood-like classical monocyte state with innate restriction features.
Genes
Most correlated modules
- Patrolling Monocyte Cytoskeleton · correlation 0.92
- Mitochondrial-biogenesis housekeeping · correlation 0.90
- Nonclassical monocyte identity · correlation 0.90
- CD16 Monocyte Signature · correlation 0.89
- Non-classical Monocyte Identity · correlation 0.89
- NF-kB Myeloid Activation · correlation 0.88
- IFN-gamma immunoproteasome · correlation 0.87
- ER Membrane Homeostasis · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.