Type I Interferon
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 31 genes have a known function matching the annotation |
Why this annotation
This is a type I IFN ISG module. It contains the SP100-family genes SP140, SP140L and SP110, plus SLFN5, BST2, LY6E, OAS1, ISG20, MOV10, TRIM14, LGALS9, IRF2, UNC93B1 and HSH2D. It is the antiviral counterpart of the IFN-gamma module M37.
Genes
Most correlated modules
- IFN-gamma response · correlation 0.82
- Type I Interferon · correlation 0.82
- BTN3A immunoregulatory · correlation 0.80
- Resting myeloid homeostasis · correlation 0.80
- IFN-gamma immunoproteasome · correlation 0.79
- IFN-induced antiviral autophagy · correlation 0.76
- High-amplitude ISG · correlation 0.76
- TNF/IFN co-activation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.