AP-1 Inflammatory Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
DUSP1 (MKP-1) is a dual-specificity phosphatase that inactivates MAP kinases and is a primary anti-inflammatory regulator in monocytes. FOS, JUN, JUNB are AP-1 transcription factors — canonical immediate early genes induced by inflammatory stimuli, LPS, and cytokines. IER2 and ZFP36 (TTP) are immediate early response genes. KLF6 is an AP-1-related transcription factor induced by stress. TRIB1 is a pseudokinase regulating monocyte-to-macrophage differentiation. COQ7 is involved in coenzyme Q biosynthesis. NAIP is an NLR inflammasome component. KCNE1 is an ion channel subunit. The high expression (1.359, 65.6%), strong AP-1/IEG signature, and significant upregulation in both UC and CD inflammation with decrease in remission indicate genuine monocyte inflammatory activation rather than dissociation artifact.
Genes
COQ7, DUSP1, FOS, IER2, JUN, JUNB, KCNE1, KLF6, NAIP, TRIB1, ZFP36
Most correlated modules
- ER Stress Response · correlation 0.61
- Immediate-Early Inflammatory · correlation 0.57
- GIMAP activation · correlation 0.52
- Monocyte Activation State · correlation 0.45
- CCR2+ Monocyte Identity · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.