BTN3A immunoregulatory
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
The core is the BTN3A1-3 cluster together with GIMAP4/6, CALCOCO2 (xenophagy receptor), MVP and RHBDF2, all modestly IFN-inducible. A DNA repair subgroup (DDB2, FANCA, FANCL, DEK) is also present. The best overall label is an IFN-associated BTN3A/xenophagy program.
Genes
Most correlated modules
- Basal endolysosomal maintenance · correlation 0.92
- Resting myeloid homeostasis · correlation 0.90
- IFN-gamma response · correlation 0.81
- Type I Interferon · correlation 0.80
- Nuclear RNA processing · correlation 0.80
- Membrane trafficking housekeeping · correlation 0.80
- Cytokine-responsive monocyte · correlation 0.77
- IFN-gamma immunoproteasome · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.