rRNA processing
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Genes include rRNA processing factors (GRWD1, BRIX1, WDR89), RNA polymerases I and III (POLR1B, POLR3H), and mitochondrial tRNA/assembly factors (TRUB2, COA7, AKAP1). POLD2 adds DNA replication. Together this is a low-level ribosome/nucleolar biogenesis program that complements M103.
Genes
Most correlated modules
- Ribosome biogenesis · correlation 0.88
- Ribosome Biogenesis · correlation 0.88
- Ribosome biogenesis · correlation 0.80
- MHC-II antigen presentation · correlation 0.78
- Nucleolar Ribosome Biogenesis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.