Ribosome Biogenesis
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 30 genes have a known function matching the annotation |
Why this annotation
This is a tightly co-regulated core module. It contains rRNA transcription and processing genes (POLR1A, HEATR1, DDX10, PUM3, NAT10, TTC27), translation genes (ABCE1, BZW2, IARS1), and nucleotide/lipid biosynthesis genes (CTPS1, ACACA). Together these form a MYC-driven ribosome biogenesis/growth program, marking a biosynthetically activated monocyte state. It is closely related to M51.
Genes
Most correlated modules
- Mitochondrial translation/metabolism · correlation 0.90
- mRNA Splicing · correlation 0.90
- rRNA processing · correlation 0.88
- Nucleolar Ribosome Biogenesis · correlation 0.86
- RNA Processing/Translation · correlation 0.86
- MHC-II antigen presentation · correlation 0.85
- ER Unfolded Protein Response · correlation 0.84
- Generic gene-expression machinery · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.