High-amplitude ISG
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ZBP1, USP18, GMPR, HESX1, NT5C3A, SHFL and RTCB are interferon-inducible. USP18 is the negative feedback regulator of IFNAR signaling, and ZBP1 is a Z-nucleic acid sensor. The low detection rate (17%) suggests a high-amplitude, late or strong ISG subset neighboring M4.
Genes
Most correlated modules
- Type I Interferon · correlation 0.91
- IFN-induced antiviral autophagy · correlation 0.88
- Type I Interferon · correlation 0.76
- IFN-gamma response · correlation 0.71
- Inflammatory CXCL10+ monocytes · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.