Secretory Vesicle Trafficking
Gene co-expression module in Monocytes
| Category | Vesicular traficking |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
STX1A (syntaxin-1A) is a SNARE protein mediating vesicle docking and fusion. SYNJ2 (synaptojanin-2) is a phosphoinositide phosphatase regulating endocytic vesicle recycling. FAM20C is a Golgi-localized kinase that phosphorylates secretory pathway proteins. ABHD17C is a depalmitoylase regulating membrane protein trafficking. These four genes define a vesicle fusion and secretory trafficking program. HMGA1 and NRIP1 are transcriptional regulators, DHRS3 is involved in retinol/lipid metabolism, SEMA3F is a secreted semaphorin. The module is a neighbor to M100 (endosomal sorting/HGS/GGA2) and M50 (autophagy/TOM1), consistent with a shared vesicular trafficking neighborhood. Lower expression and detection rate suggest a more specialized or less abundant program.
Genes
ABHD17C, CTNNBL1, DHRS3, FAM20C, HMGA1, NRIP1, PCBP3, SEMA3F, STX1A, SYNJ2
Most correlated modules
- MET Tissue Repair · correlation 0.82
- Endosomal Sorting · correlation 0.81
- Innate Immune Transcription · correlation 0.80
- Myeloid Epigenetic Regulation · correlation 0.69
- AMPK-FOXO Stress Response · correlation 0.68
- Inflammatory Autophagy · correlation 0.64
- Autophagy Initiation · correlation 0.61
- G-protein Membrane Remodeling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.