Hypoxia Response
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes HIF1A and VEGFA are canonical hypoxia-inducible factor targets driving angiogenic and metabolic adaptation. NDRG1 is a well-established HIF1A transcriptional target upregulated under hypoxia. SLC7A5 (LAT1) is a hypoxia-induced amino acid transporter. RUNX1 and ELL2 are transcription factors active in myeloid differentiation and stress responses. GNA15 is a myeloid-specific G-protein. ANPEP (CD13) and SDC4 are surface markers upregulated in activated/inflammatory monocytes. TPM4 is a cytoskeletal gene. The strong upregulation in IBD inflammation (UC and CD) with reversal in remission supports an inflammatory hypoxia-adaptation program in monocytes. SPAG9 is a JNK-interacting scaffold. The module coherently reflects HIF1A-driven hypoxic metabolic reprogramming in inflammatory monocytes.
Genes
ANPEP, ELL2, GNA15, HIF1A, NDRG1, RUNX1, SDC4, SLC7A5, SPAG9, TPM4, VEGFA
Most correlated modules
- Wnt/AP-1 Activation · correlation 0.77
- NLRP3 Inflammasome Activation · correlation 0.74
- TREM1 Inflammatory Signaling · correlation 0.70
- Inflammatory Metabolic Reprogramming · correlation 0.68
- Integrated Stress Response · correlation 0.67
- Integrin-mediated Migration · correlation 0.65
- Inflammatory Autophagy · correlation 0.62
- IgA-Monocyte Activation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.