Rho GTPase signaling
Gene co-expression module in Monocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
The hubs GNA12 (G12/13 driving RhoA), ARHGAP31, HIP1, PDE4DIP and EHD4 point to Rho GTPase/membrane-cytoskeleton signaling. Other members do not fit this program: SREBF2, PTGS1, MITF, NFE2L3, and the centrosomal/ciliary genes CEP128 and IFT172. Expression is low and uniform, so this is a mixed, weakly defined program. It neighbors M61's cytoskeletal module.
Genes
Most correlated modules
- Actin cytoskeleton remodeling · correlation 0.89
- Tec-kinase Signaling · correlation 0.87
- Translation initiation housekeeping · correlation 0.87
- Signaling/nuclear housekeeping · correlation 0.86
- Nuclear housekeeping transcripts · correlation 0.85
- Classical monocyte identity · correlation 0.84
- Golgi Vesicle Trafficking · correlation 0.84
- Protein acetylation/nuclear transport · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.