FPR1 Innate Sensing
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
FPR1 (formyl peptide receptor 1) is a key innate immune pattern recognition receptor sensing bacterial fMLF peptides and danger signals; SLC11A1 (NRAMP1) is a divalent metal transporter critical for antibacterial defense in phagosomes; SIRPB1 is a myeloid activating receptor; OSCAR activates myeloid cells; SELPLG (PSGL-1) mediates monocyte rolling on inflamed endothelium; FYN (Src kinase) transduces FPR1 and SIRP signals; CD300LF modulates myeloid activation. Strong inflammation association (delta ~3.1-3.4) with marked reduction in remission. This module represents innate immune activation via formyl peptide/pattern recognition.
Genes
CD300LF, FPR1, FYN, OSCAR, SELPLG, SIRPB1, SLC11A1, SULF2, SYTL1, TUBA1A
Most correlated modules
- Myeloid Innate Receptor Signaling · correlation 0.64
- CCR2+ Monocyte Identity · correlation 0.59
- p38 MAPK Signaling · correlation 0.57
- Pentose Phosphate Pathway · correlation 0.54
- Classical Monocyte Trafficking · correlation 0.53
- Monocyte Innate Surveillance · correlation 0.50
- Non-classical Monocyte Migration · correlation 0.49
- BPI Antibacterial Response · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.