Monocyte innate sensing
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
STAT3, PTPN2, CYBB, AOAH, TLR8 and NLRC5 are classical monocyte innate-sensing and effector genes. EPG5 and ATP6V1B2 (autophagy/lysosome) and DAPP1 add phagocyte machinery. Expression is high, broad and uniform, so this is the core monocyte identity/innate sensing program. It sits next to M74 (myeloid activation) and M202 (signalling regulation).
Genes
Most correlated modules
- Chromatin modifier transcripts · correlation 0.88
- Chromatin transcription regulators · correlation 0.87
- Tonic interferon signaling · correlation 0.86
- Antiviral restriction factors · correlation 0.84
- TFEC lysosomal program · correlation 0.82
- NF-kB feedback regulation · correlation 0.81
- Pre-mRNA splicing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.