Chromatin transcription regulators
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 26 genes have a known function matching the annotation |
Why this annotation
The genes are long, broadly expressed housekeeping and chromatin/transcription regulators: SETX, CDC73, CHD1, TOP1, RIF1, KAT2B, GPBP1 and RICTOR. There is no lineage specificity and expression is uniform. This is typical of a nuclear-retained/long-transcript or transcriptional-elongation co-detection program.
Genes
Most correlated modules
- NF-kB feedback regulation · correlation 0.89
- Long-gene housekeeping · correlation 0.88
- Ubiquitin ligase housekeeping · correlation 0.87
- Monocyte innate sensing · correlation 0.87
- Tonic interferon signaling · correlation 0.86
- Antiviral restriction factors · correlation 0.79
- Membrane trafficking housekeeping · correlation 0.79
- Pre-mRNA splicing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.