Inflammasome Signaling Regulation
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
NLRP12 is a well-characterized negative regulator of inflammasome and NF-κB signaling in neutrophils/myeloid cells. MAP2K6 (MKK6) is a direct activator of p38 MAPK, a central stress and inflammatory kinase. ADAM19 mediates ectodomain shedding of inflammatory mediators and cytokine receptors. PRKACA (PKA) modulates inflammatory signaling via cAMP. F5 (factor V) and SLC37A3 are less central but may reflect metabolic/coagulation coupling in activated neutrophils. The module's core coherence with NLRP12 and MAP2K6 as top hub genes supports an inflammasome regulatory/p38 inflammatory signaling identity. Core coherence is high, indicating a tight program.
Genes
ADAM19, F5, MAP2K6, NLRP12, PRKACA, RNF10, SLC37A3, TENM1
Most correlated modules
- Ubiquitin-Proteasome Turnover · correlation 0.90
- TLR5 Bacterial Sensing · correlation 0.88
- Mature Neutrophil Identity · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.85
- Degranulation Trafficking · correlation 0.84
- Signal Attenuation · correlation 0.84
- PI3K Migration Signaling · correlation 0.84
- Neutrophil Differentiation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.