Endocytic Vesicular Trafficking
Gene co-expression module in Neutrophils
| Category | Vesicular traficking |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRAM1 (a myeloid-expressed adaptor involved in PI3K/MAPK signaling and neutrophil differentiation), PTPN22 (a phosphatase regulating immune receptor signaling, highly relevant in myeloid cells), CLINT1 (clathrin-interacting protein in endocytic trafficking), DNAJC13 (endosomal sorting chaperone), SEC63 (ER translocon component), PHACTR2 (actin/phosphatase regulator), PRKAA1 (AMPK catalytic subunit, energy sensing), LNPK (ER morphology), and VCL (vinculin, cytoskeletal/adhesion). The combination of PRAM1+PTPN22 in neutrophils with intracellular trafficking genes (CLINT1, DNAJC13, SEC63) suggests an endosomal/vesicular trafficking program linked to immune receptor signaling. PRAM1 and PTPN22 are both known regulators of myeloid receptor signaling cascades. CLINT1 and DNAJC13 are canonical vesicular trafficking components. This module best represents an endocytic/vesicular trafficking program in the context of immune signaling in neutrophils.
Genes
CLINT1, DNAJC13, LNPK, PHACTR2, PRAM1, PRKAA1, PTPN22, SEC63, VCL
Most correlated modules
- Apoptotic Neutrophil Program · correlation 0.94
- Myeloid Lipid Remodeling · correlation 0.93
- General Homeostatic Regulation · correlation 0.90
- mRNA Splicing Processing · correlation 0.89
- Proteostasis RNA Metabolism · correlation 0.87
- Myeloid Maturation · correlation 0.82
- Neutrophil Differentiation · correlation 0.81
- Immature Neutrophil Granule · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.