Myeloid Inflammatory Activation
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
NAMPT encodes a key inflammatory mediator and rate-limiting enzyme in NAD biosynthesis, highly expressed in activated myeloid cells. LITAF drives LPS-induced TNF expression. MXD1 and AQP9 are markers of myeloid/neutrophil maturation. ITGAX (CD11c) is a myeloid integrin. FPR1 is a classical neutrophil formyl peptide receptor mediating chemotaxis and activation. TNFRSF1B (TNFR2) and SDCBP support inflammatory signaling. Together this module captures an inflammatory neutrophil activation and maturation state, neighboring the NF-κB module (M17) in the network.
Genes
AQP9, CPD, FPR1, ITGAX, LITAF, MXD1, NABP1, NAMPT, SDCBP, SLC43A2, TLE3, TNFRSF1B, TPD52L2, UBE2B
Most correlated modules
- Interferon Stimulated Genes · correlation 0.85
- C5aR Complement Activation · correlation 0.85
- Bacterial Phagocytosis Program · correlation 0.83
- TLR2 Innate Signaling · correlation 0.78
- Neutrophil Adhesion Signaling · correlation 0.78
- Phagocytic Membrane Signaling · correlation 0.77
- TLR Lipid Signaling · correlation 0.77
- NF-κB Inflammatory Transcription · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.