CC Chemokine Secretion
Gene co-expression module in Neutrophils
| Category | Cytokine & chemokine secretion |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: CCL3, CCL4L2, CCL3L3, CCL4 (CC chemokines, MIP-1 family — potent chemoattractants for monocytes, NK cells, T cells), CCL20 (recruits dendritic cells and memory T cells), CCRL2 (atypical chemokine receptor), CD83 (activation marker on APCs and activated leukocytes), C15orf48 (also known as NMES1, linked to inflammatory states), SLAMF7 (CS1, expressed on NK and activated immune cells), IL1A (pro-inflammatory cytokine), PI3 (elafin, antimicrobial peptide/protease inhibitor), CDKN1A (p21, cell cycle arrest/stress), KLF10 (TGF-beta-inducible). The dominant signature is CC chemokine secretion (CCL3/4/4L2/3L3/20) combined with inflammatory activation markers. This module represents an inflammatory neutrophil state with strong chemokine production, likely corresponding to an activated/mature neutrophil secreting CCL3/4 family members to recruit other immune cells.
Genes
C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CCRL2, CD83, CDKN1A, IL1A, KLF10, PI3, SLAMF7
Most correlated modules
- Chemokine Secretion · correlation 0.70
- Inflammasome IL-1 Response · correlation 0.55
- Neutrophil Survival Program · correlation 0.52
- NF-κB Activation · correlation 0.47
- Heat Shock Response · correlation 0.46
- Phagocytic Membrane Signaling · correlation 0.44
- NF-κB Signaling · correlation 0.40
- Inflammatory Resolution · correlation 0.40
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.