Neutrophil Differentiation
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
NFE2 is a transcription factor critical for neutrophil and megakaryocyte differentiation. S1PR4 is a sphingosine-1-phosphate receptor regulating immune cell trafficking and survival. ICAM3 (CD50) mediates leukocyte adhesion and signaling. MNDA (myeloid nuclear differentiation antigen) is a myeloid-specific transcription factor. TGFB1 is a pleiotropic cytokine involved in immune suppression and differentiation. FRAT2 is a Wnt pathway regulator. ABTB1 and MSL3 are transcriptional regulators. GCA (grancalcin) is a neutrophil granule calcium-binding protein. QPCT is expressed in mature myeloid cells. This module captures a transcriptional differentiation/maturation program in neutrophils with signaling components.
Genes
ABTB1, FRAT2, GCA, ICAM3, MANSC1, MNDA, MSL3, NFE2, QPCT, S1PR4, TGFB1
Most correlated modules
- Neutrophil Motility Cytoskeleton · correlation 0.92
- Mature Neutrophil Identity · correlation 0.90
- Endosomal Vesicle Trafficking · correlation 0.85
- S100 Alarmin Response · correlation 0.85
- Inflammasome Signaling Regulation · correlation 0.83
- Degranulation Trafficking · correlation 0.78
- Neutrophil Chemotaxis Receptors · correlation 0.78
- Pentose Phosphate Pathway · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.