MHC-I Presentation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
B2M (beta-2-microglobulin, MHC class I light chain), PSMB8 (immunoproteasome beta subunit, generates peptides for MHC-I loading), BCAP31 (ER membrane protein involved in MHC-I antigen loading and ER quality control), TMX1 (ER oxidoreductase involved in disulfide bond formation during antigen processing), CTSZ (cathepsin Z, lysosomal protease for antigen degradation), GRN (granulin, lysosomal protease regulator), ALDH2 (aldehyde dehydrogenase, metabolic but expressed in antigen-presenting cells). The module combines MHC-I antigen presentation machinery with ER quality control components. Neighbor M8 (ER folding) and M6 (lysosomal/MHC-II) support an antigen processing neighborhood.
Genes
Most correlated modules
- ER Redox Homeostasis · correlation 0.91
- Type I Interferon · correlation 0.86
- ER Protein Folding · correlation 0.82
- Clathrin-mediated Endocytosis · correlation 0.81
- Lysosomal mTOR Signaling · correlation 0.81
- Fc Receptor Trafficking · correlation 0.80
- ER-Golgi Trafficking · correlation 0.80
- Lysosomal Ag Processing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.