IFN Receptor Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 13 genes have a known function matching the annotation |
Why this annotation
IFNAR1 (interferon-alpha/beta receptor subunit 1) is directly relevant to pDC biology as pDCs are the primary producers of type I IFN and express IFNAR1 for autocrine signaling. KDM1A (LSD1, histone demethylase) and PRMT2 (protein arginine methyltransferase) are epigenetic regulators. GABPA is an ETS family transcription factor involved in IFN signaling and immune gene regulation. NUP50 (nuclear pore complex). The module is weakly coherent but IFNAR1 is a biologically meaningful hub in pDC context. The epigenetic regulators may co-regulate IFN-responsive chromatin states.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.91
- Endosomal Trafficking · correlation 0.88
- Cell Cycle Regulation · correlation 0.87
- Epigenetic Silencing · correlation 0.86
- Mixed Regulatory · correlation 0.86
- DNA Repair & Chromatin · correlation 0.86
- Transcriptional Coactivation · correlation 0.83
- Immune Cell Migration · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.