Histone Expression
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Despite weak membership and unknown coherence, the gene composition is remarkably coherent: H1-2, H1-3, H1-4, H1-5 (linker histone H1 variants), H2AC15, H2AC20 (histone H2A variants) — six of twelve genes are core histone proteins. PAIP2 (poly(A)-binding protein interacting, translation regulation), TFAM (mitochondrial transcription factor A), DMAC2L (mitochondrial complex I assembly), SMIM10L1, C8orf33, C9orf78 are the remaining genes. The histone cluster is the dominant signal. Histone gene co-expression is classically associated with S-phase/cell cycle progression (replication-dependent histones) or chromatin compaction. The uniform expression across subsets and weak membership may reflect low-level constitutive expression. This module most likely represents replication-coupled histone expression, a hallmark of proliferating cells, though the signal is weak here.
Genes
Most correlated modules
- Endosomal Trafficking · correlation 0.83
- Cell Cycle Regulation · correlation 0.82
- DNA Repair & Chromatin · correlation 0.80
- Transcriptional Regulation · correlation 0.79
- RNA Processing · correlation 0.75
- Transcription & Splicing · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.