pDC Innate Sensing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
IFIT2 is a type I interferon-stimulated gene. SLC15A4 is a pDC-specific peptide/histidine transporter essential for TLR7/9 endosomal signaling and type I IFN production. TFEC is a MiT/TFE transcription factor involved in lysosomal biogenesis. LGMN (legumain) is a lysosomal cysteine protease. BORCS5 is involved in lysosome positioning. PI4K2B is a phosphoinositide kinase on endosomes/lysosomes. MASTL is a mitotic kinase (proliferation). POLB is a DNA repair polymerase. ARHGEF3 is a Rho GEF. GLT1D1 and TMCC3 are less characterized. The module mixes ISG/antiviral (IFIT2, SLC15A4), lysosomal (LGMN, BORCS5, TFEC, PI4K2B), and some proliferation/repair genes. The pDC-specific SLC15A4 and IFIT2 suggest a pDC innate sensing/antiviral program with lysosomal components, though the module is weakly coherent.
Genes
Most correlated modules
- NF-κB Immune Signaling · correlation 0.82
- RNA Processing · correlation 0.80
- Transcriptional Regulation · correlation 0.76
- pDC Activation Response · correlation 0.76
- Chemokine Migration Response · correlation 0.73
- Heat Shock Response · correlation 0.71
- Glucocorticoid Receptor · correlation 0.70
- Type I Interferon · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.